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Issue 21, 2015
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Studies on tridecaptin B1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria

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Abstract

Previously other groups had reported that Paenibacillus polymyxa NRRL B-30507 produces SRCAM 37, a type IIA bacteriocin with antimicrobial activity against Campylobacter jejuni. Genome sequencing and isolation of antimicrobial compounds from this P. polymyxa strain show that the antimicrobial activity is due to polymyxins and tridecaptin B1. The complete structural assignment, synthesis, and antimicrobial profile of tridecaptin B1 is reported, as well as the putative gene cluster responsible for its biosynthesis. This peptide displays strong activity against multidrug resistant Gram-negative bacteria, a finding that is timely to the current problem of antibiotic resistance.

Graphical abstract: Studies on tridecaptin B1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria

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Publication details

The article was received on 19 Apr 2015, accepted on 05 May 2015 and first published on 11 May 2015


Article type: Paper
DOI: 10.1039/C5OB00780A
Citation: Org. Biomol. Chem., 2015,13, 6073-6081
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    Studies on tridecaptin B1, a lipopeptide with activity against multidrug resistant Gram-negative bacteria

    S. A. Cochrane, C. T. Lohans, M. J. van Belkum, M. A. Bels and J. C. Vederas, Org. Biomol. Chem., 2015, 13, 6073
    DOI: 10.1039/C5OB00780A

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