Issue 19, 2015
From the journal:

Organic & Biomolecular Chemistry

Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun†

Elena Pazos,a   Cecilia Portela,a   Cristina Penas,a   M. Eugenio Vázqueza  and  José L. Mascareñas*a  

* Corresponding authors

a Departamento de Química Orgánica and Centro Singular de Investigación en Química Biolóxica e Materiais Moleculares (CIQUS), Universidade de Santiago de Compostela, C/Jenaro de la Fuente s/n, Campus Vida, 15782 Santiago de Compostela, Spain
E-mail: joseluis.mascarenas@usc.es
Fax: (+34)881 815704
Tel: (+34) 881 814405

Abstract

We describe a ds-oligonucleotide–peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.

Graphical abstract: Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

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Article information

DOI
https://doi.org/10.1039/C5OB00318K
Article type
Paper
Submitted
14 Feb 2015
Accepted
03 Mar 2015
First published
03 Mar 2015

Org. Biomol. Chem., 2015,13, 5385-5390

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Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

E. Pazos, C. Portela, C. Penas, M. E. Vázquez and J. L. Mascareñas, Org. Biomol. Chem., 2015, 13, 5385 DOI: 10.1039/C5OB00318K

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