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Issue 19, 2015
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Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

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Abstract

We describe a ds-oligonucleotide–peptide conjugate that is able to efficiently dismount preformed DNA complexes of the bZIP regions of oncoproteins c-Fos and c-Jun (AP-1), and therefore might be useful as disrupters of AP-1-mediated gene expression pathways.

Graphical abstract: Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

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Publication details

The article was received on 14 Feb 2015, accepted on 03 Mar 2015 and first published on 03 Mar 2015


Article type: Paper
DOI: 10.1039/C5OB00318K
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Citation: Org. Biomol. Chem., 2015,13, 5385-5390
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    Peptide–DNA conjugates as tailored bivalent binders of the oncoprotein c-Jun

    E. Pazos, C. Portela, C. Penas, M. E. Vázquez and J. L. Mascareñas, Org. Biomol. Chem., 2015, 13, 5385
    DOI: 10.1039/C5OB00318K

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