Issue 13, 2015
From the journal:

Organic & Biomolecular Chemistry

Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage†

Jin Zhou,‡a   Canliang Fang,‡a   Ying Liu,a   Yao Zhao,a   Nan Zhang,a   Xiangjun Liu,a   Fuyi Wanga  and  Dihua Shangguan*a  

* Corresponding authors

a Beijing National Laboratory for Molecular Sciences, Key Laboratory of Analytical Chemistry for Living Biosystems, Institute of Chemistry, Chinese Academy of Sciences, Beijing, China
E-mail: sgdh@iccas.ac.cn
Fax: +86-10-62528509

Abstract

A new kind of visible-light photocleavable molecule, 4-α-amino acid substituted naphthalimide, is reported. The cleavage occurred at the C–N bond between the 4-amino and the amino acid residue and released a 4-aminonaphthalimide. A lysine substituted naphthalimide exhibited a strong DNA photocleavage activity when irradiated with a blue light LED.

Graphical abstract: Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage

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Article information

DOI
https://doi.org/10.1039/C5OB00302D
Article type
Paper
Submitted
12 Feb 2015
Accepted
12 Feb 2015
First published
12 Feb 2015

Org. Biomol. Chem., 2015,13, 3931-3935

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Visible-light-induced cleavage of 4-α-amino acid substituted naphthalimides and its application in DNA photocleavage

J. Zhou, C. Fang, Y. Liu, Y. Zhao, N. Zhang, X. Liu, F. Wang and D. Shangguan, Org. Biomol. Chem., 2015, 13, 3931 DOI: 10.1039/C5OB00302D

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