Jump to main content
Jump to site search

Issue 7, 2015
Previous Article Next Article

Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones

Author affiliations

Abstract

The exploration and expansion of the scope of the isothiourea-mediated synthesis of dihydropyridinones is presented. The use of ketimines derived from α,β-unsaturated γ-ketoesters as the Michael acceptor in a Michael addition/lactamisation cascade gives access to a range of dihydropyridinones with high enantioselectivity. The nature of the N-sulfonyl group present on the ketimine is extensively investigated, with further studies into derivatisation of the dihydropyridinone core also reported.

Graphical abstract: Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones

Back to tab navigation

Supplementary files

Publication details

The article was received on 14 Nov 2014, accepted on 02 Dec 2014 and first published on 02 Jan 2015


Article type: Paper
DOI: 10.1039/C4OB02408G
Citation: Org. Biomol. Chem., 2015,13, 2177-2191
  •   Request permissions

    Exploring the scope of the isothiourea-mediated synthesis of dihydropyridinones

    P. Yeh, D. S. B. Daniels, C. Fallan, E. Gould, C. Simal, J. E. Taylor, A. M. Z. Slawin and A. D. Smith, Org. Biomol. Chem., 2015, 13, 2177
    DOI: 10.1039/C4OB02408G

Search articles by author

Spotlight

Advertisements