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Issue 9, 2015
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Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

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Abstract

Targeting photosensitizers to cancer cells by conjugating them with specific antibodies, able to recognize and bind to tumor-associated antigens, is today one of the most attractive strategies in photodynamic therapy (PDT). This comprehensive review updates on chemical routes available for the preparation of photo-immunoconjugates (PICs), which show dual chemical and biological functionalities: photo-properties of the photosensitizer and the immunoreactivity of the antibody. Moreover, photobiological results obtained with such photo-immunoconjugates using in vitro and in vivo cancer models are also discussed.

Graphical abstract: Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

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Publication details

The article was received on 03 Nov 2014, accepted on 06 Jan 2015 and first published on 06 Jan 2015


Article type: Review Article
DOI: 10.1039/C4OB02334J
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 2518-2529
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    Antibodies armed with photosensitizers: from chemical synthesis to photobiological applications

    P. M. R. Pereira, B. Korsak, B. Sarmento, R. J. Schneider, R. Fernandes and J. P. C. Tomé, Org. Biomol. Chem., 2015, 13, 2518
    DOI: 10.1039/C4OB02334J

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