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Issue 3, 2015
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Interactions of arene ruthenium metallaprisms with human proteins

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Abstract

Interactions between three hexacationic arene ruthenium metallaprisms, [(p-cymene)6Ru6(tpt)2(dhnq)3]6+, [(p-cymene)6Ru6(tpt)2(dhbq)3]6+ and [(p-cymene)6Ru6(tpt)2(oxa)3]6+, and a series of human proteins including human serum albumin, transferrin, cytochrome c, myoglobin and ubiquitin have been studied using NMR spectroscopy, mass spectrometry and circular dichroism spectroscopy. All data suggest that no covalent adducts are formed between the proteins and the metallaprisms. Indeed, in most cases electrostatic interactions, leading to precipitation of protein-metallaprism aggregates, have been observed. In addition, with the smallest proteins, ubiquitin, myoglobin and cytochrome c, the presence of the hexacationic arene ruthenium metallaprisms induces structural changes of the proteins, as emphasized by circular dichroism. The results suggest that proteins are certainly a biological target for these metalla-assemblies.

Graphical abstract: Interactions of arene ruthenium metallaprisms with human proteins

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Publication details

The article was received on 15 Oct 2014, accepted on 12 Nov 2014 and first published on 12 Nov 2014


Article type: Paper
DOI: 10.1039/C4OB02194K
Citation: Org. Biomol. Chem., 2015,13, 946-953
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    Interactions of arene ruthenium metallaprisms with human proteins

    L. E. H. Paul, B. Therrien and J. Furrer, Org. Biomol. Chem., 2015, 13, 946
    DOI: 10.1039/C4OB02194K

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