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Issue 10, 2015
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Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

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Abstract

Cucurbiturils (CB6 and CB7) were shown to inhibit the enzymatically catalyzed restriction of plasmids and linear DNA. This effect can be inverted by supramolecular masking of the macrocycles through competitive complexation with polyamines. These experiments provide supramolecular control of biocatalytic processes.

Graphical abstract: Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

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Publication details

The article was received on 04 Oct 2014, accepted on 24 Dec 2014 and first published on 12 Jan 2015


Article type: Communication
DOI: 10.1039/C4OB02122C
Citation: Org. Biomol. Chem., 2015,13, 2866-2869
  • Open access: Creative Commons BY-NC license
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    Cucurbiturils as supramolecular inhibitors of DNA restriction by type II endonucleases

    C. Parente Carvalho, A. Norouzy, V. Ribeiro, W. M. Nau and U. Pischel, Org. Biomol. Chem., 2015, 13, 2866
    DOI: 10.1039/C4OB02122C

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