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Issue 2, 2015
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Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities

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Abstract

Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1,4-naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal assays, all compounds were inactive against the promastigote stages of L. chagasi and L. braziliensis.

Graphical abstract: Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities

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Publication details

The article was received on 01 Sep 2014, accepted on 14 Oct 2014 and first published on 14 Oct 2014


Article type: Paper
DOI: 10.1039/C4OB01869A
Citation: Org. Biomol. Chem., 2015,13, 428-437
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    Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities

    A. A. D. S. Naujorks, A. O. da Silva, R. D. S. Lopes, S. de Albuquerque, A. Beatriz, M. R. Marques and D. P. de Lima, Org. Biomol. Chem., 2015, 13, 428
    DOI: 10.1039/C4OB01869A

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