Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging

Jing Zhu; Bin Zhang; Jian Tian; Jiaqing Wang; Yu Chong; Xin Wang; Yaoyao Deng; Minghua Tang; Yonggang Li; Cuicui Ge; Yue Pan; Hongwei Gu

doi:10.1039/C4NR07255C

Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging†

Jing Zhu,‡^a Bin Zhang,‡^b Jian Tian,^c Jiaqing Wang,^a Yu Chong,^c Xin Wang,^d Yaoyao Deng,^a Minghua Tang,^e Yonggang Li,^d Cuicui Ge,*^c Yue Pan*^a and Hongwei Gu*^a

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* Corresponding authors

^a Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry, Chemical Engineering and Materials Science & Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, China
E-mail: hongwei@suda.edu.cn, panyue@suda.edu.cn

^b Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou 215006, China

^c School for Radiological and Interdisciplinary Sciences (RAD-X) & Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China
E-mail: ccge@suda.edu.cn

^d Department of Radiology, The First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, China

^e Analysis and Testing Center, Soochow University, Suzhou, China

Abstract

We report a facile synthesis of bifunctional Fe₃O₄-Ag¹²⁵I heterodimers for use as dual-modality imaging agents in magnetic resonance (MR) and single-photon emission computed tomography (SPECT). We introduced ¹²⁵I, which is a clinically used radioisotope, as a SPECT reporter, into Fe₃O₄-Ag heterodimer nanoparticles to provide a new type of bifunctional contrast agent for MRI and SPECT imaging.

Nanoscale

Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging†

Abstract

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Synthesis of heterodimer radionuclide nanoparticles for magnetic resonance and single-photon emission computed tomography dual-modality imaging

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