Jump to main content
Jump to site search

Issue 48, 2015
Previous Article Next Article

Biotechnological promises of Fe-filled CNTs for cell shepherding and magnetic fluid hyperthermia applications

Author affiliations

Abstract

Fe-filled carbon nanotubes (Fe@CNTs) recently emerged as an effective class of hybrid nanoparticles for biotechnological applications, such as magnetic cell sorting and magnetic fluid hyperthermia. Aiming at studying the effects of both the Fe loading and the magnetocrystalline characteristics in these applications, we describe herein the preparation of Fe@CNTs containing different Fe phases that, upon functionalization with the antibody Cetuximab (Ctxb), allow the targeting of cancer cells. Our experimental findings reveal that an optimal Ctxb/Fe weight ratio of 1.2 is needed for efficient magnetic cell shepherding, whereas enhanced MFH-induced mortality (70 vs. 15%) can be reached with hybrids enriched in the coercive Fe3C phase. These results suggest that a synergistic effect between the Ab loading and the Fe distribution in each nanotube exists, for which the maximum shepherding and hyperthermia effects are observed when higher densities of Fe@CNTs featuring the more coercive phase are interfaced with the cells.

Graphical abstract: Biotechnological promises of Fe-filled CNTs for cell shepherding and magnetic fluid hyperthermia applications

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Jul 2015, accepted on 31 Aug 2015 and first published on 02 Oct 2015


Article type: Paper
DOI: 10.1039/C5NR04824A
Citation: Nanoscale, 2015,7, 20474-20488
  •   Request permissions

    Biotechnological promises of Fe-filled CNTs for cell shepherding and magnetic fluid hyperthermia applications

    F. Pineux, R. Marega, A. Stopin, A. La Torre, Y. Garcia, E. Devlin, C. Michiels, A. N. Khlobystov and D. Bonifazi, Nanoscale, 2015, 7, 20474
    DOI: 10.1039/C5NR04824A

Search articles by author

Spotlight

Advertisements