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Issue 37, 2015
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Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

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Abstract

The biochemical processes of cell membranes are sensitive to the geometry of the lipid bilayer. We show how plasmonic “nanowells” provide label-free real-time analysis of molecules on membranes with detection of preferential binding at negative curvature. It is demonstrated that norovirus accumulate in invaginations due to multivalent interactions with glycosphingolipids.

Graphical abstract: Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

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Publication details

The article was received on 24 Jun 2015, accepted on 27 Aug 2015 and first published on 01 Sep 2015


Article type: Communication
DOI: 10.1039/C5NR04208A
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Citation: Nanoscale, 2015,7, 15080-15085
  • Open access: Creative Commons BY-NC license
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    Location-specific nanoplasmonic sensing of biomolecular binding to lipid membranes with negative curvature

    J. Junesch, G. Emilsson, K. Xiong, S. Kumar, T. Sannomiya, H. Pace, J. Vörös, S. Oh, M. Bally and A. B. Dahlin, Nanoscale, 2015, 7, 15080
    DOI: 10.1039/C5NR04208A

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