Jump to main content
Jump to site search

Issue 38, 2015
Previous Article Next Article

A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

Author affiliations

Abstract

Drug delivery systems (DDSs) with biocompatibility and precise drug delivery are eagerly needed to overcome the paradox in chemotherapy that high drug doses are required to compensate for the poor biodistribution of drugs with frequent dose-related side effects. In this work, we reported a metal–organic framework (MOF) based tumor targeting DDS developed by a one-pot, and organic solvent-free “green” post-synthetic surface modification procedure, starting from the nanoscale MOF MIL-101. Owing to the multifunctional surface coating, premature drug release from this DDS was prevented. Due to the pH responsive benzoic imine bond and the redox responsive disulfide bond at the modified surface, this DDS exhibited tumor acid environment enhanced cellular uptake and intracellular reducing environment triggered drug release. In vitro and in vivo results showed that DOX loaded into this DDS exhibited effective cancer cell inhibition with much reduced side effects.

Graphical abstract: A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

Back to tab navigation

Supplementary files

Publication details

The article was received on 24 Jun 2015, accepted on 24 Aug 2015 and first published on 27 Aug 2015


Article type: Paper
DOI: 10.1039/C5NR04045K
Citation: Nanoscale, 2015,7, 16061-16070
  •   Request permissions

    A multifunctional metal–organic framework based tumor targeting drug delivery system for cancer therapy

    X. Wang, Z. Dong, H. Cheng, S. Wan, W. Chen, M. Zou, J. Huo, H. Deng and X. Zhang, Nanoscale, 2015, 7, 16061
    DOI: 10.1039/C5NR04045K

Search articles by author

Spotlight

Advertisements