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Issue 23, 2015
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Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1T2 MRI contrast agents

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Abstract

We report the first study of highly monodisperse and crystalline iron oxide nanocubes with sub-nm controlled size distribution (9.7 ± 0.5 nm in size) that achieve simultaneous contrast enhancement in both T1- and T2-weighted magnetic resonance imaging (MRI). Here, we confirmed the magnetite structure of iron oxide nanocubes by X-ray diffraction (XRD), selected area electron diffraction (SAED) pattern, optical absorption and Fourier transformed infrared (FT-IR) spectra. These magnetite nanocubes exhibit superparamagnetic and paramagnetic behavior simultaneously by virtue of their finely controlled shape and size. The magnetic measurements reveal that the magnetic moment values are favorably much lower because of the small size and cubic shape of the nanoparticles, which results in an enhanced spin canting effect. As a proof-of-concept demonstration, we showed their potential as dual contrast agents for both T1- and T2-weighted MRI via phantom studies, in vivo imaging and relaxivity measurements. Therefore, these low-magnetization magnetite nanocubes, while being non-toxic and bio-compatible, hold great promise as excellent dual-mode T1 and T2 contrast agents for MRI.

Graphical abstract: Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents

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Publication details

The article was received on 02 Feb 2015, accepted on 08 May 2015 and first published on 11 May 2015


Article type: Paper
DOI: 10.1039/C5NR00752F
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Citation: Nanoscale, 2015,7, 10519-10526
  • Open access: Creative Commons BY-NC license
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    Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1T2 MRI contrast agents

    V. K. Sharma, A. Alipour, Z. Soran-Erdem, Z. G. Aykut and H. V. Demir, Nanoscale, 2015, 7, 10519
    DOI: 10.1039/C5NR00752F

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