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Issue 15, 2015
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Imaging of drug loading distributions in individual microspheres of calcium silicate hydrate – an X-ray spectromicroscopy study

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Abstract

Imaging is one of the most direct and ideal ways to track drug loading distributions in drug carriers on the molecular level, which will facilitate the optimization of drug carriers and drug loading capacities. Herein, we report the mapping of an individual mesoporous calcium silicate hydrate (CSH) microsphere before and after the loading of ibuprofen (IBU) and the interactions between drug carriers and drug molecules simultaneously by scanning transmission X-ray microscopy (STXM). Nanoscaled X-ray absorption near edge structure (XANES) spectroscopy clearly indicates that IBU is bonded to calcium and silicate sites via carboxylic acid groups. More importantly, STXM has been successfully used to determine the absolute thickness of IBU, revealing its distribution in the CSH microsphere.

Graphical abstract: Imaging of drug loading distributions in individual microspheres of calcium silicate hydrate – an X-ray spectromicroscopy study

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Publication details

The article was received on 17 Dec 2014, accepted on 11 Mar 2015 and first published on 16 Mar 2015


Article type: Paper
DOI: 10.1039/C4NR07471H
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2015,7, 6767-6773
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    Imaging of drug loading distributions in individual microspheres of calcium silicate hydrate – an X-ray spectromicroscopy study

    X. Guo, Z. Wang, J. Wu, J. Wang, Y. Zhu and T. Sham, Nanoscale, 2015, 7, 6767
    DOI: 10.1039/C4NR07471H

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