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Issue 17, 2015
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Ultra-sensitive flow measurement in individual nanopores through pressure – driven particle translocation

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Abstract

A challenge for the development of nanofluidics is to develop new instrumentation tools, able to probe the extremely small mass transport across individual nanochannels. Such tools are a prerequisite for the fundamental exploration of the breakdown of continuum transport in nanometric confinement. In this letter, we propose a novel method for the measurement of the hydrodynamic permeability of nanometric pores, by diverting the classical technique of Coulter counting to characterize a pressure-driven flow across an individual nanopore. Both the analysis of the translocation rate, as well as the detailed statistics of the dwell time of nanoparticles flowing across a single nanopore, allow us to evaluate the permeability of the system. We reach a sensitivity for the water flow down to a few femtoliters per second, which is more than two orders of magnitude better than state-of-the-art alternative methods.

Graphical abstract: Ultra-sensitive flow measurement in individual nanopores through pressure – driven particle translocation

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Publication details

The article was received on 17 Dec 2014, accepted on 29 Mar 2015 and first published on 01 Apr 2015


Article type: Paper
DOI: 10.1039/C4NR07468H
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2015,7, 7965-7970
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    Ultra-sensitive flow measurement in individual nanopores through pressure – driven particle translocation

    A. Gadaleta, A. Biance, A. Siria and L. Bocquet, Nanoscale, 2015, 7, 7965
    DOI: 10.1039/C4NR07468H

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