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Issue 6, 2015
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Large pore mesoporous silica nanomaterials for application in delivery of biomolecules

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Abstract

Various approaches for the synthesis of mesoporous silicate nanoparticles (MSN) with large pore (LP) diameters (in the range of 3–50 nm) are reviewed in this article. The work also covers the construction of magnetic analogues of large pore-mesoporous silica nanoparticles (LPMMSN) and their biomedical applications. The constructed materials exhibit vast potential for application in the loading and delivery of large drug molecules and biomolecules. Literature reports on the application of LPMSN and LPMMSN materials for the adsorption and delivery of proteins, enzymes, antibodies, and nucleic acids are covered in depth, which exemplify their highly potent characteristics for use in drug and biomolecule delivery to diseased tissues.

Graphical abstract: Large pore mesoporous silica nanomaterials for application in delivery of biomolecules

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Publication details

The article was received on 16 Oct 2014, accepted on 29 Dec 2014 and first published on 30 Dec 2014


Article type: Review Article
DOI: 10.1039/C4NR06114D
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Citation: Nanoscale, 2015,7, 2199-2209
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    Large pore mesoporous silica nanomaterials for application in delivery of biomolecules

    N. Ž. Knežević and J. Durand, Nanoscale, 2015, 7, 2199
    DOI: 10.1039/C4NR06114D

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