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Issue 5, 2015
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Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging

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Abstract

Magnetic resonance based molecular imaging has emerged as a very promising technique for early detection and treatment of a wide variety of diseases, including cancer, neurodegenerative disorders, and vascular diseases. The limited sensitivity and specificity of conventional MRI are being overcome by the development of a new generation of contrast agents, using nanotechnology approaches, with improved magnetic and biological properties. In particular, for molecular imaging, high specificity, high sensitivity, and long blood circulation times are required. Furthermore, the lack of toxicity and immunogenicity together with low-cost scalable production are also necessary to get them into the clinics. In this work, we describe a facile, robust and cost-effective ligand-exchange method to synthesize dual T1 and T2 MRI contrast agents with long circulation times. These contrast agents are based on manganese ferrite nanoparticles (MNPs) between 6 and 14 nm in size covered by a 3 kDa polyethylene glycol (PEG) shell that leads to a great stability in aqueous media with high crystallinity and magnetization values, thus retaining the magnetic properties of the uncovered MNPs. Moreover, the PEGylated MNPs have shown different relaxivities depending on their size and the magnetic field applied. Thus, the 6 nm PEGylated MNPs are characterized by a low r2/r1 ratio of 4.9 at 1.5 T, hence resulting in good dual T1 and T2 contrast agents under low magnetic fields, whereas the 14 nm MNPs behave as excellent T2 contrast agents under high magnetic fields (r2 = 335.6 mM−1 s−1). The polymer core shell of the PEGylated MNPs minimizes their cytotoxicity, and allows long blood circulation times. This combination of cellular compatibility and excellent T2 and r2/r1 values under low magnetic fields, together with long circulation times, make these nanomaterials very promising contrast agents for molecular imaging.

Graphical abstract: Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging

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Publication details

The article was received on 02 Oct 2014, accepted on 12 Dec 2014 and first published on 16 Dec 2014


Article type: Paper
DOI: 10.1039/C4NR05781C
Author version available: Download Author version (PDF)
Citation: Nanoscale, 2015,7, 2050-2059
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    Long-circulating PEGylated manganese ferrite nanoparticles for MRI-based molecular imaging

    M. Pernia Leal, S. Rivera-Fernández, J. M. Franco, D. Pozo, J. M. de la Fuente and M. L. García-Martín, Nanoscale, 2015, 7, 2050
    DOI: 10.1039/C4NR05781C

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