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Issue 4, 2015
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Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

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Abstract

Covering: up to 2014

In this review we investigate the use of complex ester fragment couplings within natural product total synthesis campaigns. We first outline the different biosynthetic and chemical strategies for performing complex ester couplings and on this mechanistic background we then present and discuss a collection of successful examples from the literature.

Graphical abstract: Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

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Publication details

The article was received on 12 Aug 2014 and first published on 09 Jan 2015


Article type: Review Article
DOI: 10.1039/C4NP00106K
Citation: Nat. Prod. Rep., 2015,32, 605-632
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    Ester coupling reactions – an enduring challenge in the chemical synthesis of bioactive natural products

    M. Tsakos, E. S. Schaffert, L. L. Clement, N. L. Villadsen and T. B. Poulsen, Nat. Prod. Rep., 2015, 32, 605
    DOI: 10.1039/C4NP00106K

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