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Issue 4, 2015
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Ecofriendly synthesis of halogenated flavonoids and evaluation of their antifungal activity

Roberta Bernini,*a  Marcella Pasqualetti,b  Gianfranco Provenzanoa  and  Sabrina Tempestab 
Author affiliations

* Corresponding authors

a Dipartimento di Scienze e Tecnologie per l'Agricoltura, le Foreste, la Natura e l'Energia (DAFNE), Università degli Studi della Tuscia, Via S. Camillo De Lellis, 01100 Viterbo, Italy
E-mail: berninir@unitus.it
Fax: +39 0761 357242
Tel: +39 0761 357452

b Dipartimento di Scienze Ecologiche e Biologiche (DEB), Università degli Studi della Tuscia, Largo dell'Università, 01100 Viterbo, Italy

Abstract

Brominated and chlorinated flavonoids belonging to different classes (flavanones, flavones and catechins) were prepared from the corresponding flavonoids by a simple and ecofriendly procedure based on the use of sodium halides, aqueous hydrogen peroxide and acetic acid. Pure samples of substrates and products were tested against Trichoderma koningii, Fusarium oxysporum and Cladosporium cladosporioides, common saprotrophic soil and seed fungi, potential pathogens for humans and their activity was expressed as linear mycelial growth inhibition (%). Among them, 8-chloro-5,7,3′,4′-tetramethoxyepicatechin 29, a novel catechin derivative, exhibited a remarkable effect against all tested fungi also at low concentrations.

Graphical abstract: Ecofriendly synthesis of halogenated flavonoids and evaluation of their antifungal activity

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Publication details

The article was received on 29 Jan 2015, accepted on 02 Feb 2015 and first published on 02 Feb 2015


Article type: Paper
DOI: 10.1039/C5NJ00258C
Author version available: Download Author version (PDF)
Citation: New J. Chem., 2015,39, 2980-2987
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    Ecofriendly synthesis of halogenated flavonoids and evaluation of their antifungal activity

    R. Bernini, M. Pasqualetti, G. Provenzano and S. Tempesta, New J. Chem., 2015, 39, 2980
    DOI: 10.1039/C5NJ00258C

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