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Issue 6, 2015
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Piperazine derivatives of boronic acids – potential bifunctional biologically active compounds

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Abstract

The combination of a piperazine and boronic groups within one molecule can result in a totally novel biological activity. A series of benzyl piperazine derivatives of boronic acids have been obtained by the facile and effective method based on the amination-reduction reaction of 2-formylphenylboronic acid with N-substituted piperazines. The molecular and crystal structures of six novel derivatives have been investigated, along with Hirshfeld surface analysis and hydrogen bond energy estimation. The studied compounds display several structural features that make them promising candidates as biologically active compounds.

Graphical abstract: Piperazine derivatives of boronic acids – potential bifunctional biologically active compounds

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Publication details

The article was received on 12 Jan 2015, accepted on 16 Mar 2015 and first published on 17 Mar 2015


Article type: Paper
DOI: 10.1039/C5NJ00084J
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Citation: New J. Chem., 2015,39, 4308-4315
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    Piperazine derivatives of boronic acids – potential bifunctional biologically active compounds

    A. Adamczyk-Woźniak, K. Czerwińska, I. D. Madura, A. Matuszewska, A. Sporzyński and A. Żubrowska-Zembrzuska, New J. Chem., 2015, 39, 4308
    DOI: 10.1039/C5NJ00084J

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