N-Heterocyclic carbene-catalyzed synthesis of functionalized 3-hydroxypyrrolidinones via a domino aza-Michael/aldol reaction†
Abstract
A practical and efficient synthesis of functionalized 3-hydroxypyrrolidinones through a domino aza-Michael/aldol reaction of α-ketoamides with chalcone has been realized. The domino reaction proceeded smoothly with NHC as a catalyst, affording 3-hydroxypyrrolidinones in good to excellent yields with excellent functional group tolerance.