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Issue 10, 2015
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2-[18F]Fluoroethyl tosylate – a versatile tool for building 18F-based radiotracers for positron emission tomography

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Abstract

Positron emission tomography (PET) is a modern in vivo imaging technique and an important diagnostic modality for clinical and pre-clinical research. The incorporation of a radionuclide like fluorine-18 into a target molecule to form PET radiopharmaceuticals is a repeated challenge for radiochemists. [18F]Fluoroethylation is a well-acknowledged method for 18F-radiolabeling and 2-[18F]fluoroethyl tosylate ([18F]FETs) is a preferred reagent because of its high reactivity to phenolic, thiophenolic, carboxylic and amide functionalities. This review will highlight the role of [18F]FETs in PET chemistry and summarize its applicability in radiotracer design. The radiolabeling conditions and the pros and cons of direct and indirect radiolabeling as well the aspects of the reactivity of [18F]FETs compared with other [18F]fluoroalkylating reagents will be discussed comprehensively.

Graphical abstract: 2-[18F]Fluoroethyl tosylate – a versatile tool for building 18F-based radiotracers for positron emission tomography

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Publication details

The article was received on 17 Jul 2015, accepted on 01 Sep 2015 and first published on 03 Sep 2015


Article type: Review Article
DOI: 10.1039/C5MD00303B
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Citation: Med. Chem. Commun., 2015,6, 1714-1754
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    2-[18F]Fluoroethyl tosylate – a versatile tool for building 18F-based radiotracers for positron emission tomography

    T. Kniess, M. Laube, P. Brust and J. Steinbach, Med. Chem. Commun., 2015, 6, 1714
    DOI: 10.1039/C5MD00303B

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