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Issue 7, 2015
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Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Abstract

Emerging evidence suggests bromodomain-containing proteins 7 and 9 (BRD7 and BRD9) have roles in the regulation of human transcription and disease including cancer. We describe potent and selective inhibitors of the BRD7 and BRD9 bromodomains intended for use as tools to elucidate the biological roles of BRD7 and BRD9 in healthy and diseased cells.

Graphical abstract: Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

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Publication details

The article was received on 13 Apr 2015, accepted on 10 Jun 2015 and first published on 15 Jun 2015


Article type: Concise Article
DOI: 10.1039/C5MD00152H
Citation: Med. Chem. Commun., 2015,6, 1381-1386
  • Open access: Creative Commons BY license
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    Design and synthesis of potent and selective inhibitors of BRD7 and BRD9 bromodomains

    D. A. Hay, C. M. Rogers, O. Fedorov, C. Tallant, S. Martin, O. P. Monteiro, S. Müller, S. Knapp, C. J. Schofield and P. E. Brennan, Med. Chem. Commun., 2015, 6, 1381
    DOI: 10.1039/C5MD00152H

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