Jump to main content
Jump to site search

Issue 5, 2015
Previous Article Next Article

Synthesis and protective effect of new ligustrazine derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells. Part 2

Author affiliations

Abstract

Ligustrazine-benzoic acid derivatives which exhibited promising neuroprotective activities have previously been reported. To further improve the neuroprotective effect of ligustrazine, a series of new ligustrazine derivatives was synthesized and evaluated for their protective effect against cobalt chloride-induced neurotoxicity in differentiated PC12 cells. Most compounds exhibited higher activity than ligustrazine, of which, we found compound (E)-(3,5,6-trimethylpyrazin-2-yl)methyl 3-(2,3,4-trimethoxyphenyl)acrylate (9) displayed the highest protective effect on the PC12 cells damaged by CoCl2 (EC50 = 0.719 μM). Structure–activity relationships are briefly discussed.

Graphical abstract: Synthesis and protective effect of new ligustrazine derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells. Part 2

Back to tab navigation

Supplementary files

Publication details

The article was received on 09 Dec 2014, accepted on 01 Feb 2015 and first published on 12 Feb 2015


Article type: Concise Article
DOI: 10.1039/C4MD00552J
Citation: Med. Chem. Commun., 2015,6, 806-809
  •   Request permissions

    Synthesis and protective effect of new ligustrazine derivatives against CoCl2-induced neurotoxicity in differentiated PC12 cells. Part 2

    B. Xu, Y. Gong, X. Xu, C. Zhang, Y. Zhang, F. Chu, H. Liu, P. Wang and H. Lei, Med. Chem. Commun., 2015, 6, 806
    DOI: 10.1039/C4MD00552J

Search articles by author

Spotlight

Advertisements