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Issue 4, 2015
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Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides

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Abstract

Incorporation of 2′-O-methyl-2-thioribothymidine (s2Tm) into antisense oligoribonucleotides significantly enhanced the exon skipping activity in Duchenne muscular dystrophy model mice.

Graphical abstract: Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides

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Publication details

The article was received on 15 Oct 2014, accepted on 15 Nov 2014 and first published on 08 Dec 2014


Article type: Concise Article
DOI: 10.1039/C4MD00468J
Author version available: Download Author version (PDF)
Citation: Med. Chem. Commun., 2015,6, 630-633
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    Enhancement of exon skipping in mdx52 mice by 2′-O-methyl-2-thioribothymidine incorporation into phosphorothioate oligonucleotides

    Y. Masaki, T. Inde, T. Nagata, J. Tanihata, T. Kanamori, K. Seio, S. Takeda and M. Sekine, Med. Chem. Commun., 2015, 6, 630
    DOI: 10.1039/C4MD00468J

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