Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

Shantimoy Kar; Uddipta Ghosh; Tapas Kumar Maiti; Suman Chakraborty

doi:10.1039/C5LC00968E

Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

Shantimoy Kar,^a Uddipta Ghosh,^b Tapas Kumar Maiti*^a^c and Suman Chakraborty*^a^b

Author affiliations

* Corresponding authors

^a Advanced Technology Development Centre, Indian Institute of Technology Kharagpur, Kharagpur-721302, India
E-mail: suman@mech.iitkgp.ernet.in

^b Department of Mechanical Engineering, Indian Institute of Technology Kharagpur, Kharagpur-721302, India

^c Department of Biotechnology, Indian Institute of Technology Kharagpur, Kharagpur-721302, India

Abstract

We investigate the deformation characteristics of red blood cells (RBCs) on a rotating compact disc platform. Our study brings out the interplay between haemoglobin content and RBC deformability in a centrifugally actuated microfluidic environment. We reveal that RBC deformations follow the similar trend of principal stress distributed throughout the radial direction, rendering an insight into the mechano-physical processes involved. This study can be used as a diagnostic marker to determine haematological disorders in diseased blood samples tested on compact disc based microfluidic platforms.

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Publication details

The article was received on 12 Aug 2015, accepted on 12 Oct 2015 and first published on 12 Oct 2015

Article type: Paper

DOI: 10.1039/C5LC00968E

Author version available: Download Author version (PDF)

Citation: Lab Chip, 2015,15, 4571-4577

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Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

S. Kar, U. Ghosh, T. K. Maiti and S. Chakraborty, Lab Chip, 2015, 15, 4571
DOI: 10.1039/C5LC00968E
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Lab on a Chip

Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

Abstract

Supplementary files

Publication details

Haemoglobin content modulated deformation dynamics of red blood cells on a compact disc

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