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Issue 18, 2015
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A programmable microfluidic static droplet array for droplet generation, transportation, fusion, storage, and retrieval

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Abstract

We present a programmable microfluidic static droplet array (SDA) device that can perform user-defined multistep combinatorial protocols. It combines the passive storage of aqueous droplets without any external control with integrated microvalves for discrete sample dispensing and dispersion-free unit operation. The addressable picoliter-volume reaction is systematically achieved by consecutively merging programmable sequences of reagent droplets. The SDA device is remarkably reusable and able to perform identical enzyme kinetic experiments at least 30 times via automated cross-contamination-free removal of droplets from individual hydrodynamic traps. Taking all these features together, this programmable and reusable universal SDA device will be a general microfluidic platform that can be reprogrammed for multiple applications.

Graphical abstract: A programmable microfluidic static droplet array for droplet generation, transportation, fusion, storage, and retrieval

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Publication details

The article was received on 12 Jun 2015, accepted on 23 Jul 2015 and first published on 27 Jul 2015


Article type: Paper
DOI: 10.1039/C5LC00651A
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Citation: Lab Chip, 2015,15, 3677-3686
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    A programmable microfluidic static droplet array for droplet generation, transportation, fusion, storage, and retrieval

    S. H. Jin, H. Jeong, B. Lee, S. S. Lee and C. Lee, Lab Chip, 2015, 15, 3677
    DOI: 10.1039/C5LC00651A

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