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Issue 18, 2015
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Simultaneous MEMS-based electro-mechanical phenotyping of breast cancer

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Abstract

Carcinomas are the most commonly diagnosed cancers originating in the skin, lungs, breasts, pancreas, and other organs and glands. In most of the cases, the microenvironment within the tissue changes with the progression of disease. A key challenge is to develop a device capable of providing quantitative indicators in diagnosing cancer by measuring alteration in electrical and mechanical property of the tissues from the onset of malignancy. We demonstrate micro-electro-mechanical-systems (MEMS) based flexible polymer microsensor array capable of simultaneously measuring electro-mechanical properties of the breast tissues cores (1 mm in diameter and 10 μm in thickness) from onset through progression of the cancer. The electrical and mechanical signatures obtained from the tissue cores shows the capability of the device to clearly demarcate the specific stages of cancer in epithelial and stromal regions providing quantitative indicators facilitating the diagnosis of breast cancer. The present study shows that electro-mechanical properties of the breast tissue core at the micro-level are different than those at the macro-level.

Graphical abstract: Simultaneous MEMS-based electro-mechanical phenotyping of breast cancer

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Publication details

The article was received on 29 Apr 2015, accepted on 13 Jul 2015 and first published on 16 Jul 2015


Article type: Paper
DOI: 10.1039/C5LC00491H
Citation: Lab Chip, 2015,15, 3695-3706
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    Simultaneous MEMS-based electro-mechanical phenotyping of breast cancer

    H. J. Pandya, K. Park, W. Chen, M. A. Chekmareva, D. J. Foran and J. P. Desai, Lab Chip, 2015, 15, 3695
    DOI: 10.1039/C5LC00491H

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