Jump to main content
Jump to site search

Issue 14, 2015
Previous Article Next Article

Microscale extraction and phase separation using a porous capillary

Author affiliations

Abstract

We report the use of a porous polytetrafluoroethylene capillary for the inline separation of liquid–liquid segmented flows, based on the selective wetting and permeation of the porous capillary walls by one of the liquids. Insertion of a narrow flow restriction at the capillary outlet allows the back pressure to be tuned for multiple liquid–liquid combinations and flow conditions. In this way, efficient separation of aqueous–organic, aqueous–fluorous and organic–fluorous segmented flows can be readily achieved over a wide range of flow rates. The porous-capillary-separator enables the straightforward regeneration of a continuous flow from a segmented flow, and may be applied to various applications, including inline analysis, biphasic reactions, and purification. As a demonstration of the latter, we performed a simple inline aqueous–organic extraction of the pH indicator 2,6-dichloroindophenol. An aqueous solution of the conjugate base was mixed with hydrochloric acid in continuous flow to protonate the indicator and render it organic-soluble. The indicator was then extracted from the aqueous feed into chloroform using a segmented flow. The two liquids were finally separated inline using a porous PTFE capillary, with the aqueous phase emerging as a continuous stream from the separator outlet. UV-visible absorption spectroscopy showed the concentration of indicator in the outflowing aqueous phase to be less than one percent of its original value, confirming the efficacy of the extraction and separation process.

Graphical abstract: Microscale extraction and phase separation using a porous capillary

Back to tab navigation

Publication details

The article was received on 13 Apr 2015, accepted on 19 May 2015 and first published on 09 Jun 2015


Article type: Paper
DOI: 10.1039/C5LC00430F
Citation: Lab Chip, 2015,15, 2960-2967
  • Open access: Creative Commons BY license
  •   Request permissions

    Microscale extraction and phase separation using a porous capillary

    T. W. Phillips, J. H. Bannock and J. C. deMello, Lab Chip, 2015, 15, 2960
    DOI: 10.1039/C5LC00430F

    This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. Material from this article can be used in other publications provided that the correct acknowledgement is given with the reproduced material.

    Reproduced material should be attributed as follows:

    • For reproduction of material from NJC:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the Centre National de la Recherche Scientifique (CNRS) and the RSC.
    • For reproduction of material from PCCP:
      [Original citation] - Published by the PCCP Owner Societies.
    • For reproduction of material from PPS:
      [Original citation] - Published by The Royal Society of Chemistry (RSC) on behalf of the European Society for Photobiology, the European Photochemistry Association, and RSC.
    • For reproduction of material from all other RSC journals:
      [Original citation] - Published by The Royal Society of Chemistry.

    Information about reproducing material from RSC articles with different licences is available on our Permission Requests page.

Search articles by author

Spotlight

Advertisements