Issue 14, 2015

3D silicon neural probe with integrated optical fibers for optogenetic modulation

Abstract

Optogenetics is a powerful modality for neural modulation that can be useful for a wide array of biomedical studies. Penetrating microelectrode arrays provide a means of recording neural signals with high spatial resolution. It is highly desirable to integrate optics with neural probes to allow for functional study of neural tissue by optogenetics. In this paper, we report the development of a novel 3D neural probe coupled simply and robustly to optical fibers using a hollow parylene tube structure. The device shanks are hollow tubes with rigid silicon tips, allowing the insertion and encasement of optical fibers within the shanks. The position of the fiber tip can be precisely controlled relative to the electrodes on the shank by inherent design features. Preliminary in vivo rat studies indicate that these devices are capable of optogenetic modulation simultaneously with 3D neural signal recording.

Graphical abstract: 3D silicon neural probe with integrated optical fibers for optogenetic modulation

Article information

Article type
Paper
Submitted
16 Dec 2014
Accepted
03 Jun 2015
First published
04 Jun 2015

Lab Chip, 2015,15, 2939-2949

Author version available

3D silicon neural probe with integrated optical fibers for optogenetic modulation

E. G. R. Kim, H. Tu, H. Luo, B. Liu, S. Bao, J. Zhang and Y. Xu, Lab Chip, 2015, 15, 2939 DOI: 10.1039/C4LC01472C

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