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Issue 14, 2015
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3D silicon neural probe with integrated optical fibers for optogenetic modulation

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Abstract

Optogenetics is a powerful modality for neural modulation that can be useful for a wide array of biomedical studies. Penetrating microelectrode arrays provide a means of recording neural signals with high spatial resolution. It is highly desirable to integrate optics with neural probes to allow for functional study of neural tissue by optogenetics. In this paper, we report the development of a novel 3D neural probe coupled simply and robustly to optical fibers using a hollow parylene tube structure. The device shanks are hollow tubes with rigid silicon tips, allowing the insertion and encasement of optical fibers within the shanks. The position of the fiber tip can be precisely controlled relative to the electrodes on the shank by inherent design features. Preliminary in vivo rat studies indicate that these devices are capable of optogenetic modulation simultaneously with 3D neural signal recording.

Graphical abstract: 3D silicon neural probe with integrated optical fibers for optogenetic modulation

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Publication details

The article was received on 16 Dec 2014, accepted on 03 Jun 2015 and first published on 04 Jun 2015


Article type: Paper
DOI: 10.1039/C4LC01472C
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2015,15, 2939-2949
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    3D silicon neural probe with integrated optical fibers for optogenetic modulation

    E. G. R. Kim, H. Tu, H. Luo, B. Liu, S. Bao, J. Zhang and Y. Xu, Lab Chip, 2015, 15, 2939
    DOI: 10.1039/C4LC01472C

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