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Issue 5, 2015
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In vitro evaluation and in vivo demonstration of a biomimetic, hemocompatible, microfluidic artificial lung

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Abstract

Despite the promising potential of microfluidic artificial lungs, current designs suffer from short functional lifetimes due to surface chemistry and blood flow patterns that act to reduce hemocompatibility. Here, we present the first microfluidic artificial lung featuring a hemocompatible surface coating and a biomimetic blood path. The polyethylene-glycol (PEG) coated microfluidic lung exhibited a significantly improved in vitro lifetime compared to uncoated controls as well as consistent and significantly improved gas exchange over the entire testing period. Enabled by our hemocompatible PEG coating, we additionally describe the first extended (3 h) in vivo demonstration of a microfluidic artificial lung.

Graphical abstract: In vitro evaluation and in vivo demonstration of a biomimetic, hemocompatible, microfluidic artificial lung

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Publication details

The article was received on 29 Oct 2014, accepted on 07 Jan 2015 and first published on 08 Jan 2015


Article type: Paper
DOI: 10.1039/C4LC01284D
Author version available: Download Author version (PDF)
Citation: Lab Chip, 2015,15, 1366-1375
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    In vitro evaluation and in vivo demonstration of a biomimetic, hemocompatible, microfluidic artificial lung

    K. M. Kovach, M. A. LaBarbera, M. C. Moyer, B. L. Cmolik, E. van Lunteren, A. Sen Gupta, J. R. Capadona and J. A. Potkay, Lab Chip, 2015, 15, 1366
    DOI: 10.1039/C4LC01284D

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