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Issue 2, 2015
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An integrated centrifugo-opto-microfluidic platform for arraying, analysis, identification and manipulation of individual cells

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Abstract

In this work we present a centrifugal microfluidic system enabling highly efficient collective trapping and alignment of particles such as microbeads and cells, their multi-colour fluorescent detection and subsequent manipulation by optical tweezers. We demonstrate array-based capture and imaging followed by “cherry-picking” of individual particles, first for fluorescently labelled polystyrene (PS) beads and then for cells. Different cell lines are discriminated based on intracellular as well as surface-based markers.

Graphical abstract: An integrated centrifugo-opto-microfluidic platform for arraying, analysis, identification and manipulation of individual cells

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Publication details

The article was received on 28 Aug 2014, accepted on 17 Oct 2014 and first published on 12 Nov 2014


Article type: Technical Innovation
DOI: 10.1039/C4LC01002G
Citation: Lab Chip, 2015,15, 378-381
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    An integrated centrifugo-opto-microfluidic platform for arraying, analysis, identification and manipulation of individual cells

    R. Burger, D. Kurzbuch, R. Gorkin, G. Kijanka, M. Glynn, C. McDonagh and J. Ducrée, Lab Chip, 2015, 15, 378
    DOI: 10.1039/C4LC01002G

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