Issue 5, 2015

Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

Abstract

Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.

Graphical abstract: Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

Supplementary files

Article information

Article type
Paper
Submitted
19 Feb 2015
Accepted
17 Mar 2015
First published
17 Mar 2015
This article is Open Access
Creative Commons BY license

Green Chem., 2015,17, 3000-3009

Author version available

Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

A. Harsanyi and G. Sandford, Green Chem., 2015, 17, 3000 DOI: 10.1039/C5GC00402K

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