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Issue 8, 2015
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Glycine catalyzed diastereoselective domino-synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in water

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Abstract

The first example of glycine-catalyzed direct domino synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in aqueous medium is described, giving products in excellent yields and moderate to excellent diastereoselectivities. This approach provides a highly efficient and environmentally benign access to cyano-substituted 2,7-dioxabicyclo[3.2.1]octane.

Graphical abstract: Glycine catalyzed diastereoselective domino-synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in water

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Publication details

The article was received on 29 Apr 2015, accepted on 04 Jun 2015 and first published on 04 Jun 2015


Article type: Paper
DOI: 10.1039/C5GC00909J
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Citation: Green Chem., 2015,17, 4234-4238
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    Glycine catalyzed diastereoselective domino-synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles in water

    O. V. Ershov, M. Yu. Ievlev, V. A. Tafeenko and O. E. Nasakin, Green Chem., 2015, 17, 4234
    DOI: 10.1039/C5GC00909J

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