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Issue 5, 2015
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Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

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Abstract

Optimisation and real time reaction monitoring of the synthesis of 2-fluoromalonate esters by direct fluorination using fluorine gas is reported. An assessment of green metrics including atom economy and process mass intensity factors, demonstrates that the one-step selective direct fluorination process compares very favourably with established multistep processes for the synthesis of fluoromalonates.

Graphical abstract: Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

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The article was received on 19 Feb 2015, accepted on 17 Mar 2015 and first published on 17 Mar 2015


Article type: Paper
DOI: 10.1039/C5GC00402K
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Citation: Green Chem., 2015,17, 3000-3009
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    Fluorine gas for life science syntheses: green metrics to assess selective direct fluorination for the synthesis of 2-fluoromalonate esters

    A. Harsanyi and G. Sandford, Green Chem., 2015, 17, 3000
    DOI: 10.1039/C5GC00402K

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