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Issue 2, 2015
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One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

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Abstract

We describe novel chemoenzymatic routes to (S)-benzylisoquinoline and (S)-tetrahydroprotoberberine alkaloids using the enzymes transaminase (TAm) and norcoclaurine synthase (NCS) in a one-pot, one-substrate ‘triangular’ cascade. Employment of up to two C–C bond forming steps allows for the rapid generation of molecular complexity under mild conditions.

Graphical abstract: One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

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Publication details

The article was received on 25 Nov 2014, accepted on 12 Dec 2014 and first published on 18 Dec 2014


Article type: Communication
DOI: 10.1039/C4GC02325K
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Citation: Green Chem., 2015,17, 852-855
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    One-pot triangular chemoenzymatic cascades for the syntheses of chiral alkaloids from dopamine

    B. R. Lichman, E. D. Lamming, T. Pesnot, J. M. Smith, H. C. Hailes and J. M. Ward, Green Chem., 2015, 17, 852
    DOI: 10.1039/C4GC02325K

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