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Issue 12, 2015
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Potent inhibitory effect of silibinin from milk thistle on skin inflammation stimuli by 12-O-tetradecanoylphorbol-13-acetate

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Abstract

Silibinin, a major polyphenol in milk thistle, has been reported to have multiple pharmacological activities; therefore, there is an urgent need to well understand how silibinin works on inflammation-associated skin diseases. We herein designed silibinin on 12-O-tetradecanoylphorbol-13-acetate (TPA)-stimulated skin inflammation to test its inhibitory effects. It was demonstrated that silibinin, applied topically onto mouse ears following TPA stimulation, effectively down-regulated the expressions of TPA-induced interleukin-1β (IL-1β), interleukin-6 (IL-6), necrosis factor-alpha (TNF-α) and cyclooxygenase-2 (COX-2) in a dose-dependent manner. Further mechanistic investigations indicated that silibinin suppressed the expression of IκB kinase (IKK) by inhibiting the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway, and thereby suppressing TPA-stimulated nuclear factor-κB (NF-κB) activation. Promisingly, silibinin, used for transdermal application, may be a potent naturally occuring anti-inflammatory agent for the prevention of inflammation-associated skin diseases.

Graphical abstract: Potent inhibitory effect of silibinin from milk thistle on skin inflammation stimuli by 12-O-tetradecanoylphorbol-13-acetate

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Publication details

The article was received on 22 Jul 2015, accepted on 20 Aug 2015 and first published on 24 Aug 2015


Article type: Paper
DOI: 10.1039/C5FO00899A
Author version available: Download Author version (PDF)
Citation: Food Funct., 2015,6, 3712-3719
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    Potent inhibitory effect of silibinin from milk thistle on skin inflammation stimuli by 12-O-tetradecanoylphorbol-13-acetate

    W. Liu, Y. Li, X. Zheng, K. Zhang and Z. Du, Food Funct., 2015, 6, 3712
    DOI: 10.1039/C5FO00899A

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