Jump to main content
Jump to site search

Issue 6, 2015
Previous Article Next Article

Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver

Author affiliations

Abstract

This study aims to determine whether pterostilbene improves glycaemic control in rats showing insulin resistance induced by an obesogenic diet. Rats were divided into 3 groups: the control group and two groups treated with either 15 mg kg−1 d−1 (PT15) or 30 mg kg−1 d−1 of pterostilbene (PT30). HOMA-IR was decreased in both pterostilbene-treated groups, but this reduction was greater in the PT15 group (−45% and −22% respectively vs. the control group). The improvement of glycaemic control was not due to a delipidating effect of pterostilbene on skeletal muscle. In contrast, GLUT4 protein expression was increased (+58% and +52% vs. the control group), suggesting an improved glucose uptake. The phosphorylated-Akt/total Akt ratio was significantly enhanced in the PT30 group (+25%), and therefore a more efficient translocation of GLUT4 is likely. Additionally, in this group the amount of cardiotrophin-1 was significantly increased (+65%). These data suggest that the effect of pterostilbene on Akt is mediated by this cytokine. In the liver, glucokinase activity was significantly increased only in the PT15 group (+34%), and no changes were observed in glucose-6-phosphatase activity. The beneficial effect of pterostilbene on glycaemic control was more evident with the lower dose, probably because in the PT15 group both the muscle and the liver were contributing to this effect, but in the PT30 group only the skeletal muscle was responsible. In conclusion, pterostilbene improves glycaemic control in rats showing insulin resistance induced by an obesogenic diet. An increase in hepatic glucokinase activity, as well as in skeletal muscle glucose uptake, seems to be involved in the anti-diabetic effect of this phenolic compound.

Graphical abstract: Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver

Back to tab navigation

Publication details

The article was received on 11 Feb 2015, accepted on 08 May 2015 and first published on 11 May 2015


Article type: Paper
DOI: 10.1039/C5FO00151J
Author version
available:
Download author version (PDF)
Citation: Food Funct., 2015,6, 1968-1976
  •   Request permissions

    Pterostilbene improves glycaemic control in rats fed an obesogenic diet: involvement of skeletal muscle and liver

    S. Gómez-Zorita, A. Fernández-Quintela, L. Aguirre, M. T. Macarulla, A. M. Rimando and M. P. Portillo, Food Funct., 2015, 6, 1968
    DOI: 10.1039/C5FO00151J

Search articles by author

Spotlight

Advertisements