Modeling of the hydrophobic microenvironment of water-soluble molybdoenzymes in an aqueous micellar solution

Yuki Hasenaka; Taka-aki Okamura; Kiyotaka Onitsuka

doi:10.1039/C5DT01112D

Modeling of the hydrophobic microenvironment of water-soluble molybdoenzymes in an aqueous micellar solution

Yuki Hasenaka,^a Taka-aki Okamura*^a and Kiyotaka Onitsuka^a

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^a Department of Macromolecular Science, Graduate School of Science, Osaka University, Toyonaka, Japan
E-mail: tokamura@chem.sci.osaka-u.ac.jp
Fax: +81 6 6850 5474
Tel: +81 6 6850 5451

Abstract

A toluene-soluble molybdenum(VI) complex containing a bulky hydrophobic substituent, (Et₄N)₂[Mo^VIO₂{1,2-S₂-3,6-(RCONH)₂C₆H₂}₂] (R = (4-^tBuC₆H₄)₃C), was dissolved in the hydrophobic core of a micelle in an aqueous medium and catalyzed the biomimetic reduction of an amine N-oxide by an NADH analog. The kinetic isotope effect of solvent water clearly indicates that water molecules are essential for catalysis and are involved in the rate-determining step.

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Publication details

The article was received on 20 Mar 2015, accepted on 28 May 2015 and first published on 29 May 2015

Article type: Paper

DOI: 10.1039/C5DT01112D

Citation: Dalton Trans., 2015,44, 12618-12622

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Modeling of the hydrophobic microenvironment of water-soluble molybdoenzymes in an aqueous micellar solution

Y. Hasenaka, T. Okamura and K. Onitsuka, Dalton Trans., 2015, 44, 12618
DOI: 10.1039/C5DT01112D
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Modeling of the hydrophobic microenvironment of water-soluble molybdoenzymes in an aqueous micellar solution

Abstract

Supplementary files

Publication details

Modeling of the hydrophobic microenvironment of water-soluble molybdoenzymes in an aqueous micellar solution

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