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Issue 15, 2015
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Mesityl phenanthroline-modified 2′-deoxyuridine for heteroleptic complexes in metal ion-mediated assembly of DNA

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Abstract

The synthesis of a new DNA building block that bears the metal ion ligand 2,9-bis-mesityl-3-ethynyl-phenanthroline attached to the 5-position of 2′-deoxyuridine is presented. In the presence of Zn2+, Cu2+, Fe2+ and Ni2+ the complex formation of an accordingly modified DNA double strand with a second DNA duplex bearing the 2,2′:6′,2′′-terpyridine ligand was studied by optical spectroscopy. The selective formation of heteroleptic assemblies between the two different DNA pieces was evidenced by denaturing polyacrylamide gel electrophoresis.

Graphical abstract: Mesityl phenanthroline-modified 2′-deoxyuridine for heteroleptic complexes in metal ion-mediated assembly of DNA

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Publication details

The article was received on 09 Jan 2015, accepted on 11 Mar 2015 and first published on 12 Mar 2015


Article type: Communication
DOI: 10.1039/C5DT00100E
Citation: Dalton Trans., 2015,44, 6715-6718
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    Mesityl phenanthroline-modified 2′-deoxyuridine for heteroleptic complexes in metal ion-mediated assembly of DNA

    P. Ensslen and H. Wagenknecht, Dalton Trans., 2015, 44, 6715
    DOI: 10.1039/C5DT00100E

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