Jump to main content
Jump to site search

Issue 16, 2015
Previous Article Next Article

Synthesis and anticancer activity of silver(I)–N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

Author affiliations

Abstract

A new library of silver(I)–N-heterocyclic carbene complexes prepared from the natural products caffeine, theophylline and theobromine is reported. The complexes have been fully characterised using a combination of NMR spectroscopy, mass spectrometry, elemental analysis and X-ray diffraction analysis. Furthermore, the hydrophobicity of the complexes has been measured. The silver(I)–N-heterocyclic carbenes have been evaluated for their antiproliferative properties against a range of cancer cell lines of different histological types, and compared to cisplatin. The data shows different profiles of response when compared to cisplatin in the same panel of cells, indicating a different mechanism of action. Furthermore, it appears that the steric effect of the ligand and the hydrophobicity of the complex both play a role in the chemosensitivity of these compounds, with greater steric bulk and greater hydrophilicity delivering higher cytotoxicity.

Graphical abstract: Synthesis and anticancer activity of silver(i)–N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

Back to tab navigation

Supplementary files

Publication details

The article was received on 01 Dec 2014, accepted on 15 Mar 2015 and first published on 26 Mar 2015


Article type: Paper
DOI: 10.1039/C4DT03679D
Author version available: Download Author version (PDF)
Citation: Dalton Trans., 2015,44, 7563-7569
  •   Request permissions

    Synthesis and anticancer activity of silver(I)–N-heterocyclic carbene complexes derived from the natural xanthine products caffeine, theophylline and theobromine

    H. A. Mohamed, B. R. M. Lake, T. Laing, R. M. Phillips and C. E. Willans, Dalton Trans., 2015, 44, 7563
    DOI: 10.1039/C4DT03679D

Search articles by author

Spotlight

Advertisements