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Issue 7, 2015
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Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

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Abstract

The complexes [RuCp*(PP)Cl] (Cp* = C5Me5; [1], PP = dppm; [4], PP = Xantphos), [RuCp#(PP)Cl] (Cp# = C5Me4(CH2)5OH; [2], PP = dppm; [5], PP = Xantphos) and [RuCp*(dppm)(CH3CN)][SbF6] [3] were synthesized and evaluated in vitro as anticancer agents. Compounds 1–3 gave nanomolar IC50 values against normoxic A2780 and HT-29 cell lines, and were also tested against hypoxic HT-29 cells, maintaining their high activity. Complex 3 yielded an IC50 value of 0.55 ± 0.03 μM under a 0.1% O2 concentration.

Graphical abstract: Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

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Publication details

The article was received on 09 Sep 2014, accepted on 28 Dec 2014 and first published on 05 Jan 2015


Article type: Paper
DOI: 10.1039/C4DT02748E
Author version available: Download Author version (PDF)
Citation: Dalton Trans., 2015,44, 3265-3270
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    Synthesis and anticancer activity evaluation of η5-C5(CH3)4R ruthenium complexes bearing chelating diphosphine ligands

    A. Rodríguez-Bárzano, R. M. Lord, A. M. Basri, R. M. Phillips, A. J. Blacker and P. C. McGowan, Dalton Trans., 2015, 44, 3265
    DOI: 10.1039/C4DT02748E

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