Issue 10, 2015
From the journal:

Catalysis Science & Technology

Enantioselective conjugate addition of cyanide to chalcones catalyzed by a magnesium-Py-BINMOL complex†

Cheng Dong,a   Tao Song,a   Xing-Feng Bai,ab   Yu-Ming Cui,a   Zheng Xua  and  Li-Wen Xu*ab  

* Corresponding authors

a Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education, and College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310012, PR China
E-mail: liwenxu@hznu.edu.cn
Fax: +86 2886 5135
Tel: 86 2886 5135

b State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, PR China
E-mail: licpxulw@yahoo.com

Abstract

An enantioselective magnesium-catalyzed conjugate addition of trimethylsilyl cyanide to chalcones in the presence of Py-BINMOL with multiple stereogenic centers, through dual activation of substrates, has been successfully developed with moderate to good enantioselectivities and in good yields.

Graphical abstract: Enantioselective conjugate addition of cyanide to chalcones catalyzed by a magnesium-Py-BINMOL complex

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Article information

DOI
https://doi.org/10.1039/C5CY01056J
Article type
Communication
Submitted
12 Jul 2015
Accepted
12 Aug 2015
First published
17 Aug 2015

Catal. Sci. Technol., 2015,5, 4755-4759

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Enantioselective conjugate addition of cyanide to chalcones catalyzed by a magnesium-Py-BINMOL complex

C. Dong, T. Song, X. Bai, Y. Cui, Z. Xu and L. Xu, Catal. Sci. Technol., 2015, 5, 4755 DOI: 10.1039/C5CY01056J

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