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Issue 11, 2015
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Vitamin B12 catalysed reactions

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Vitamin B12 (cobalamin, 1) is one of a few naturally occurring organometallic molecules. As a cofactor for adenosylcobalamin-dependent and methylcobalamin-dependent enzymes, it plays a crucial role in biological processes, including DNA synthesis and regulation, nervous system function, red blood cell formation, etc. Enzymatic reactions, such as isomerisation, dehalogenation, and methyl transfer, rely on the formation and cleavage of the Co–C bond. Because it is a natural, nontoxic, environmentally benign cobalt complex, cobalamin (1) has been successfully utilised in organic synthesis as a catalyst for Co-mediated reactions. This tutorial review concisely describes cobalamin-catalysed organic reactions that hold promise for environmentally friendly cobalt catalysis, leaving the reader with basic knowledge and the ability to harness the catalytic potential of this fascinating molecule.

Graphical abstract: Vitamin B12 catalysed reactions

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Publication details

The article was received on 20 Feb 2015 and first published on 06 May 2015

Article type: Tutorial Review
DOI: 10.1039/C5CS00165J
Author version available: Download Author version (PDF)
Citation: Chem. Soc. Rev., 2015,44, 3391-3404
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    Vitamin B12 catalysed reactions

    M. Giedyk, K. Goliszewska and D. Gryko, Chem. Soc. Rev., 2015, 44, 3391
    DOI: 10.1039/C5CS00165J

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