Jump to main content
Jump to site search

Issue 7, 2015
Previous Article Next Article

Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

Author affiliations

Abstract

Brain amyloid depositions are the main hallmarks of Alzheimer's and other protein misfolding diseases. Since they are believed to precede clinical symptoms by several years, imaging of such fibrillar aggregates is particularly suitable to diagnose the onset of the disease in its early stage and monitor its progression. In this context, near infrared (NIR) imaging has been proposed as a promising and non-invasive method to visualize amyloid plaques in vivo because of its acceptable depth of penetration and minimal degree of tissue damage. In this tutorial review, we describe the main chemical and physicochemical features of probes associated with fluorescence emission in the NIR region. The review focuses on the recent progress and improvements in the development of small-molecule NIR fluorescent probes and their in vivo application in living animals. In addition, the possible therapeutic application of NIR probes to block the pathological aggregation process will be discussed, raising the fascinating possibility of their exploitation as theranostic agents.

Graphical abstract: Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

Back to tab navigation

Publication details

The article was received on 10 Oct 2014 and first published on 27 Jan 2015


Article type: Tutorial Review
DOI: 10.1039/C4CS00337C
Author version
available:
Download author version (PDF)
Citation: Chem. Soc. Rev., 2015,44, 1807-1819
  •   Request permissions

    Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

    M. Staderini, M. A. Martín, M. L. Bolognesi and J. C. Menéndez, Chem. Soc. Rev., 2015, 44, 1807
    DOI: 10.1039/C4CS00337C

Search articles by author

Spotlight

Advertisements