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Issue 14, 2015
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Fluorometric imaging methods for palladium and platinum and the use of palladium for imaging biomolecules

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Abstract

Neither palladium nor platinum is an endogenous biological metal. Imaging palladium in biological samples, however, is becoming increasingly important because bioorthogonal organometallic chemistry involves palladium catalysis. In addition to being an imaging target, palladium has been used to fluorometrically image biomolecules. In these cases, palladium species are used as imaging-enabling reagents. This review article discusses these fluorometric methods. Platinum-based drugs are widely used as anticancer drugs, yet their mechanism of action remains largely unknown. We discuss fluorometric methods for imaging or quantifying platinum in cells or biofluids. These methods include the use of chemosensors to directly detect platinum, fluorescently tagging platinum-based drugs, and utilizing post-labeling to elucidate distribution and mode of action.

Graphical abstract: Fluorometric imaging methods for palladium and platinum and the use of palladium for imaging biomolecules

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Publication details

The article was received on 27 Sep 2014 and first published on 23 Feb 2015


Article type: Review Article
DOI: 10.1039/C4CS00323C
Citation: Chem. Soc. Rev., 2015,44, 4769-4791
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    Fluorometric imaging methods for palladium and platinum and the use of palladium for imaging biomolecules

    M. P. Tracey, D. Pham and K. Koide, Chem. Soc. Rev., 2015, 44, 4769
    DOI: 10.1039/C4CS00323C

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