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Issue 43, 2015
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Bio-mediated synthesis, characterization and cytotoxicity of gold nanoparticles

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Abstract

We report here a “green” approach for the synthesis of gold nanoparticles (GNPs) in which the Mentha piperita extract was applied for the bioreduction of chloroauric acid and the stabilization of the formed nanostructures. The obtained GNPs were characterized by UV-Vis absorption spectroscopy and transmission electron microscopy (TEM). The reduction of gold ions with the plant extract leads to the production of nanoparticles with various shapes (spherical, triangular and hexagonal) and sizes (from 10 to 300 nm). The kinetics of the reaction was monitored and various conditions of the synthesis were investigated. As a result, we established protocols optimized towards the synthesis of nanospheres and nanoprisms of gold. The cytotoxic effect of the obtained gold nanoparticles was studied by performing MTT assay, which showed lower cytotoxicity of the biosynthesized GNPs compared to gold nanorods synthesized using the usual seed-mediated growth. The results suggest that the synthesis using plant extracts may be a useful method to produce gold nanostructures for various biological and medical applications.

Graphical abstract: Bio-mediated synthesis, characterization and cytotoxicity of gold nanoparticles

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Publication details

The article was received on 19 Mar 2015, accepted on 27 Sep 2015 and first published on 28 Sep 2015


Article type: Paper
DOI: 10.1039/C5CP01619C
Author version available: Download Author version (PDF)
Citation: Phys. Chem. Chem. Phys., 2015,17, 29014-29019
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    Bio-mediated synthesis, characterization and cytotoxicity of gold nanoparticles

    M. Klekotko, K. Matczyszyn, J. Siednienko, J. Olesiak-Banska, K. Pawlik and M. Samoc, Phys. Chem. Chem. Phys., 2015, 17, 29014
    DOI: 10.1039/C5CP01619C

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