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Issue 15, 2015
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The n → π* interaction: a rapidly emerging non-covalent interaction

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Abstract

This perspective describes the current status of a recently discovered non-covalent interaction named as the n → π* interaction, which is very weak and counterintuitive in nature. In this review, we have provided a brief overview of the widespread presence of this interaction in biomacromolecules, small biomolecules and materials, as well as the physical nature of this interaction explored using various experimental and theoretical techniques. It has been found that this interaction is equally important to other non-covalent interactions for the stability and specific structures of biomolecules and materials. An in-depth understanding of this interaction can help in designing more efficient functional materials as well as drugs. The review also provides a future outlook in terms of exploring the detailed functional role of this interaction in biological processes and its direct spectroscopic evidence, which other commonly known non-covalent interactions (conventional hydrogen bonding, π-hydrogen bonding, π-stacking, etc.) have.

Graphical abstract: The n → π* interaction: a rapidly emerging non-covalent interaction

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Publication details

The article was received on 28 Nov 2014, accepted on 03 Mar 2015 and first published on 03 Mar 2015


Article type: Perspective
DOI: 10.1039/C4CP05536E
Citation: Phys. Chem. Chem. Phys., 2015,17, 9596-9612
  • Open access: Creative Commons BY license
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    The n → π* interaction: a rapidly emerging non-covalent interaction

    S. K. Singh and A. Das, Phys. Chem. Chem. Phys., 2015, 17, 9596
    DOI: 10.1039/C4CP05536E

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