Issue 63, 2015

Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications

Abstract

The efficient conjugation of a ruthenium complex and the peptide hormone somatostatin is presented. The resultant biohybrid offers valuable features for photodynamic therapy such as remarkable cellular selectivity, rapid cell uptake by receptor-mediated endocytosis, efficient generation of 1O2 upon irradiation, potent phototoxicity as well as low cytotoxicity in the “off”-state.

Graphical abstract: Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications

Supplementary files

Article information

Article type
Communication
Submitted
26 Apr 2015
Accepted
30 Jun 2015
First published
30 Jun 2015

Chem. Commun., 2015,51, 12552-12555

Receptor selective ruthenium-somatostatin photosensitizer for cancer targeted photodynamic applications

T. Wang, N. Zabarska, Y. Wu, M. Lamla, S. Fischer, K. Monczak, D. Y. W. Ng, S. Rau and T. Weil, Chem. Commun., 2015, 51, 12552 DOI: 10.1039/C5CC03473F

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