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Issue 40, 2015
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Ultrasensitive electrochemical immunoassay of proteins based on in situ duple amplification of gold nanoparticle biolabel signals

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Abstract

An electrochemical sandwich immunoassay method that can be sensitive to a few protein molecules (human immunoglobulin G or human prostate-specific antigen) is reported, based on HAuCl4–NH2OH redox reaction to enlarge the size of second antibody labeled gold nanoparticles and in situ microliter-droplet anodic stripping voltammetry analysis with enhanced cathodic preconcentration of gold.

Graphical abstract: Ultrasensitive electrochemical immunoassay of proteins based on in situ duple amplification of gold nanoparticle biolabel signals

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Publication details

The article was received on 16 Feb 2015, accepted on 09 Apr 2015 and first published on 10 Apr 2015


Article type: Communication
DOI: 10.1039/C5CC01439E
Citation: Chem. Commun., 2015,51, 8540-8543
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    Ultrasensitive electrochemical immunoassay of proteins based on in situ duple amplification of gold nanoparticle biolabel signals

    X. Qin, A. Xu, L. Liu, W. Deng, C. Chen, Y. Tan, Y. Fu, Q. Xie and S. Yao, Chem. Commun., 2015, 51, 8540
    DOI: 10.1039/C5CC01439E

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